Sarah Samorodnitsky

This study uses spatial transcriptomics and single-cell analysis to reveal how MDS bone marrow microenvironments are altered, showing TGFβ dysregulation in malignant cells and immune escape mechanisms.

The paper introduces TOASTER, a method that uses topological data analysis to associate spatial protein expression with patient outcomes without relying on cell segmentation or phenotyping.

This paper introduces TopKAT, a topology-based method to detect associations between spatial cell structures and clinical outcomes in spatial proteomics data.

The paper introduces SPOT, a method to assess spatial clustering in proteomic data across multiple radii, and demonstrates its application in ovarian cancer.