Antoni Ribas

CytoRipple identifies tissue-level polarization vector fields from spatial multi-omic data to reveal multi-cellular structures and their functional associations.

SpaceBender denoises spatial transcriptomics data by leveraging spatial information, improving biological signal clarity and statistical significance in simulations and real tissues.

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

The paper develops a high-throughput platform to profile antigen-specific CD4+ T cells at single-cell resolution, identifying immunogenic features and functional heterogeneity in viral and cancer contexts.

This study identifies SPP1+ macrophages as key drivers of resistance to CAR T therapy in solid tumors and shows that targeting SPP1 can overcome this resistance.

The paper introduces SPOT, a method to assess spatial clustering in proteomic data across multiple radii, and demonstrates its application in ovarian cancer.

IRIS identifies cancer immunotherapy targets from alternative splicing using transcriptomics data and validates them with patient T cells.

The paper predicts MHC anchor positions for 328 HLA alleles and shows that incorporating these improves neoantigen identification by correcting misclassified candidates in tumor samples.

This study develops a method for single-cell and whole-genome sequencing of frozen clinical specimens, demonstrating its utility in analyzing tumor evolution and rare disease biospecimens.

The paper evaluates nucleic acid extraction kits and RNA sequencing library preparations for FFPE clinical samples, finding that combinations of methods affect transcriptome analysis.

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.

The paper evaluates pre-analytical factors affecting plasma DNA analysis by comparing DNA extraction methods and blood collection tubes using a multiplexed ddPCR assay.