Systems BiologyMolecular Systems BiologyPeer-reviewed
Glycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Severin Josef Schink, Dimitris Christodoulou, Avik Mukherjee…·Markus Basan
The paper investigates trade-offs in microbial central carbon metabolism, showing that glycolytic and gluconeogenic pathways cannot be optimized simultaneously due to regulatory limitations.