Gary Andrew Bradshaw

The paper identifies K63-linked ubiquitin chains as a sorting signal for ciliary ectocytosis, showing that ubiquitinated inactive Smoothened is packaged into ciliary extracellular vesicles.

This study shows STMN2 stabilizes by binding to tubulin, reducing its membrane localization and degradation, and proposes its neuroprotective role depends on its membrane-bound form.

This study identifies IMPG2m as a BBSome cargo in photoreceptors, revealing a constitutive ciliary retrieval pathway involving ubiquitinated membrane proteins.

The paper uses proximity proteomics to study the cardiac dyad in heart failure, identifying Galectin-1 as a positive modulator of cardiac contractility and relaxation.

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

The paper identifies TYK2 as a potential therapeutic target for neurodegenerative diseases by linking cdsRNA-induced inflammation to interferon signaling and demonstrating protective effects of TYK2 inhibitors.

This paper identifies HUWE1 as a ubiquitin ligase that enhances ubiquitin modifications on proteins and aggregates, promoting their degradation via proteasome and autophagy pathways.

This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.

The paper investigates trade-offs in microbial central carbon metabolism, showing that glycolytic and gluconeogenic pathways cannot be optimized simultaneously due to regulatory limitations.