Author

V. S. Sundar

University of California San DiegoORCID 0000-0001-7933-828XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:GWAS summary statistics· 3 Research Focus:fine-mapping· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anders Martin DaleiD· 3 shared Chun Chieh FaniD· 3 shared Dominic HollandiD· 3 shared Alexey A. ShadriniD· 2 shared Olav Bjerkehagen SmelandiD· 2 shared Ole A. AndreasseniD· 2 shared Oleksandr FreiiD· 2 shared Brent D. AulstoniD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersGenomics

Anders Martin DaleORCID

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4 papers

Recent·Most cited

NeuroscienceNeuronPeer-reviewedDec 1, 2023

Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function

Leonardo A Parra‐Rivas, Kayalvizhi Madhivanan, Brent D. Aulston…·Subhojit Roy

This study shows that phosphorylation of α-synuclein at Serine-129 is a physiologic trigger for protein interactions and synaptic function, challenging its previous association with pathology.

127 citationstop 1%

proteomicsstatistical model

𝕏 PostBluesky

GenomicsPLoS GeneticsPeer-reviewedMay 19, 2020

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

Dominic Holland, Oleksandr Frei, Rahul S. Desikan…·Anders Martin Dale

The paper estimates polygenicity and discoverability of causal SNPs for human traits using a univariate Gaussian mixture model applied to GWAS summary statistics.

239 citationstop 1%

humanGWAS summary statistics

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BioinformaticsbioRxivPreprintJun 27, 2018

MODE for detecting and estimating genetic causal variants

V. S. Sundar, Chun-Chieh Fan, Dominic Holland, Anders Martin Dale

The paper introduces MODE, a method for simultaneous fine-mapping and effect size estimation of genetic causal variants using correlated Gaussian/non-Gaussian random variables.

DOI 10.1101/357228

GWAS summary statisticsstatistical model

𝕏 PostBluesky

GenomicsbioRxivPreprintJul 21, 2017

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

Dominic Holland, Chun Chieh Fan, Oleksandr Frei…·Anders Martin Dale

The paper estimates residual inflation in GWAS summary statistics caused by cryptic relatedness and shows correction reduces significant loci for height and schizophrenia.

10 citations

humanGWAS summary statistics

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