The MYCN 5' UTR as a therapeutic target in neuroblastoma
Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries, Bandana Sharma, Alyssa L. Kennedy, John A. Jr. Porco, Rani E. George
This study investigates the therapeutic potential of targeting eIF4A1 to inhibit MYCN expression in neuroblastoma by exploiting its role in translation of polypurine-rich 5' UTRs.
Cell Reports · Apr 23, 2024Peer-reviewedCancer Biology