Rani E. George

The paper identifies USP48 as a regulator of chromatin stability and DNA damage response to hypomethylating agents, showing its loss increases susceptibility to these drugs in AML.

The paper identifies PP121 and bufalin as drugs that induce differentiation in retinoic acid-resistant neuroblastoma cells through miR-124 activation, maintaining differentiated states for over 16 weeks.

This study shows CDK12/13 inhibition disrupts nucleolar structure and causes aberrant IGS rRNA transcript expression due to impaired processing and degradation.

This study investigates the therapeutic potential of targeting eIF4A1 to inhibit MYCN expression in neuroblastoma by exploiting its role in translation of polypurine-rich 5' UTRs.

Giotto is a toolbox for analyzing and visualizing spatial transcriptomic and proteomic data, offering integration with single-cell RNA-seq and supporting diverse datasets.

This study develops a mouse-human neural crest chimera model to study human neuroblastoma development and immune interactions in vivo.