Author

Karla I. De la O Becerra

Utrecht UniversityORCID 0000-0001-7965-0572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Itziar Serna MartiniD· 1 shared Piet GrosiD· 1 shared T. Harma C. BrondijkiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Itziar Serna MartinORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedDec 18, 2025

Structural insights into C3 convertase activity of the classical pathway of complement

Karla I. De la O Becerra, T. Harma C. Brondijk, Itziar Serna Martin, Piet Gros

The paper presents cryo-EM structures of classical pathway complement convertases and their substrate complex, revealing mechanisms of C3 cleavage and opsonin production.

6 citations

cryo-EMexperimental assay

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