Molecular BiologybioRxivPreprint
Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation
Sivareddy Kotla, Jonghae Lee, Kyung Ae Ko…·Jun‐ichi Abe
This study shows that loss of LATS1/2 in endothelial cells promotes a senescence-associated stemness (SAS) state, leading to atherothrombotic plaque formation through metabolic and mitochondrial dysregulation.