Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation
Sivareddy Kotla, Jonghae Lee, Kyung Ae Ko, Weiqing Chen, Venkata Subrahman K Samanthapudi, Oanh N. Hoang, Gilbert F. Mejia, Shengyu Li, Keri Schadler, Luis Antonio Rivera, Masaki Imanishi, Kay Carlene Tavares Samperio, Jung Hyun Kim, Keila Carolina Ostos Mendoza, Karla N. Mariscal-Reyes, , Jun‐ichi Abe
This study shows that loss of LATS1/2 in endothelial cells promotes a senescence-associated stemness (SAS) state, leading to atherothrombotic plaque formation through metabolic and mitochondrial dysregulation.
bioRxiv · Jun 19, 2025 · PreprintMolecular Biology