Visual-like 2D Geometric Template Diffusion for Boosting Single-Sequence Protein Structure Prediction
Xudong Wang, Tong Zhang, Zhen Cui, Xu Guo, Fuyun Wang, Yuanzhi Wang, Xing Cai, Wenming Zheng
TDFold improves single-sequence protein structure prediction using a 2D geometric template diffusion method, outperforming existing models on homology-insufficient datasets and offering lower resource consumption and faster inference.
bioRxiv · Jul 3, 2025 · PreprintBioinformatics