Xu Guo

This study shows that venetoclax resistance in AML creates a vulnerability to canonical pyroptosis, which can be targeted with DPP8/9 inhibitors and NLRP3 activators.

This study identifies a metabolic-signaling circuit in RAS-mutant cancers driven by GA3P, which enhances SOS1-RAS interaction and sustains oncogenic activity through MAZ-GLUT6 glucose reprogramming.

TDFold improves single-sequence protein structure prediction using a 2D geometric template diffusion method, outperforming existing models on homology-insufficient datasets and offering lower resource consumption and faster inference.