BiophysicsbioRxivPreprint
Dimerisation and twist reversal of the Lewy fold in α-synuclein mutants with Parkinson's disease and dementia
Hongwei Zhang, Alexey G. Murzin, Jennifer A. Macdonald…·Michel Goedert
The paper reports the structures of α-synuclein filaments from individuals with Parkinson's disease and dementia, revealing differences in dimerisation and twist reversal between pathogenic and non-pathogenic variants.