Author

Daisuke Taniguchi

Juntendo UniversityORCID 0000-0002-8729-7016Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Alexey G. Murzin· 1 shared Ayami OkuzumiiD· 1 shared Bernardino Francesco GhettiiD· 1 shared Catarina de Matos Ferraz FrancoiD· 1 shared Daisuke NoshiroiD· 1 shared Daita KanedaiD· 1 shared Emi Kawauchi· 1 shared Etsu TashiroiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Alexey G. Murzin

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2 papers

Recent·Most cited

Dimerisation and twist reversal of the Lewy fold in α-synuclein mutants with Parkinson's disease and dementia

Hongwei Zhang, Alexey G. Murzin, Jennifer A. Macdonald, Tiara V. Hinton, Sew‐Yeu Peak‐Chew, Catarina de Matos Ferraz Franco, Patrick W. Cullinane, Thomas T. Warner, Ayami Okuzumi, Raquel Real, Kenya Nishioka, Daisuke Taniguchi, Daita Kaneda, Huw R. Morris, Henry Houlden, , Michel Goedert

The paper reports the structures of α-synuclein filaments from individuals with Parkinson's disease and dementia, revealing differences in dimerisation and twist reversal between pathogenic and non-pathogenic variants.

bioRxiv · Apr 9, 2026 · PreprintBiophysics

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation

Tomoki Takei, Yukiko Sasazawa, Daisuke Noshiro, Mitsuhiro Kitagawa, Tetsushi Kataura, Hiroko Hirawake‐Mogi, Emi Kawauchi, Yuya Nakano, Etsu Tashiro, Tsuyoshi Saitoh, Shigeru Nishiyama, Seiichiro Ogawa, Soichiro Kakuta, Saiko Kazuno, Yoshiki Miura, , Nobutaka Hattori

This study shows that ubiquilin-2 droplets catalyze α-synuclein fibril formation in vitro and in cells, and identifies a compound that inhibits this process.

The EMBO Journal · Oct 14, 2025Peer-reviewedBiochemistry