Author

John P. Kane

University of California, San FranciscoORCID 0000-0001-8049-3850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Clive R. PullingeriD· 3 shared Barry I. FreedmaniD· 2 shared Brian E. CadeiD· 2 shared Donald W. BowdeniD· 2 shared Donna K. ArnettiD· 2 shared Edwin K. SilvermaniD· 2 shared Eric BoerwinkleiD· 2 shared Gregory M. MarcusiD· 2 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Clive R. PullingerORCID

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 7, 2026

Functional characterization of hypertriglyceridemia-associated mutations in Lipase Maturation Factor 1 by a second-generation activity assay

Candy Bedoya, Parmis Rejali, Xanden Mccleary…·Miklós Péterfy

This paper develops a new assay to functionally analyze LMF1 variants linked to hypertriglyceridemia, identifying 12 loss-of-function variants and highlighting Loop C as a critical region.

DOI 10.64898/2026.09.03.749245

humanproteomics

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Genetic & Genomic MedicineJournal of the American Heart AssociationPeer-reviewedDec 12, 2023

APOL1 Risk Variants Associate with the Prevalence of Stroke in African American Current and Past Smokers

Jelena Mustra Rakic, Clive R. Pullinger, Erin L. Van Blarigan…·John P. Kane

The paper investigates the interaction between APOL1 risk variants and smoking in African Americans, finding that carriers of these variants have increased stroke risk among smokers.

5 citations

humanstatistical model

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GeneticsNaturePeer-reviewedApr 12, 2023

Clonal hematopoiesis is driven by aberrant activation of TCL1A

Joshua S. Weinstock, Jayakrishnan Gopakumar, Bala Bharathi Burugula…·Rasika A. Mathias

The paper develops PACER to infer clonal expansion rates from single timepoint data and identifies TCL1A activation as a mediator of clonal hematopoiesis fitness.

115 citationstop 1%

humanbulk RNA-seq

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GenomicsbioRxivPreprintJan 25, 2023

Structural variation across 138,134 samples in the TOPMed consortium

Goo Jun, Adam C. English, Ginger Metcalf…·Fritz Joachim Sedlazeck

The paper presents a comprehensive catalog of structural variants across 138,134 individuals, identifying novel variants and their associations with cardio-metabolic and hematologic traits.

24 citations

humanwhole-genome sequencing

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