Genetic & Genomic MedicinemedRxivPreprint
Clinical history shapes the predictive value of polygenic risk
Dmitrii Usoltsev, Иван Игоревич Молотков, Nikita Kolosov…·Mykyta Artomov
The paper develops and validates polygenic risk scores (PRS) for 150 diseases and mortality using UK Biobank and FinnGen data, showing genetic information provides the largest predictive gains for certain diseases but not others.