Nikita Kolosov

Clinical history shapes the predictive value of polygenic risk

The paper develops and validates polygenic risk scores (PRS) for 150 diseases and mortality using UK Biobank and FinnGen data, showing genetic information provides the largest predictive gains for certain diseases but not others.

Quantifying the contribution of genetic variation to healthcare expenditure across diverse healthcare systems

This study identifies genetic variants associated with healthcare costs across multiple systems, finding polygenic influences and large effects from specific loss-of-function variants.

PGS Browser: a public platform for personalized polygenic score interpretation

The paper benchmarks polygenic scores in a large cohort, identifies top-performing models, and provides a public platform for PGS analysis and interpretation.

Understanding Complex Trait Susceptibilities and Ethnical Diversity in a Sample of 4,145 Russians Through Analysis of Clinical and Genetic Data

The paper analyzes genetic and phenotypic data from 4,145 Russians to explore ethnic diversity and genetic associations, finding enrichment of Finnish-specific variants and providing a GWAS database.

Prioritization of disease genes from GWAS using ensemble based positive-unlabeled learning

This paper introduces GPrior, a gene prioritization tool that improves disease gene identification from GWAS by using ensemble positive-unlabeled learning.