NeurosciencebioRxivPreprint
Structural Analysis of Simultaneous Activation and Inhibition of Gamma-Secretase Activity in Development of Drugs for Alzheimers disease
Željko M. Svedružić, Katarina Vrbnjak, Manuel Martinović, Vedran Miletić
The paper investigates how biphasic drugs and pathogenic mutations affect gamma-secretase activity, showing they modulate amyloid-beta production through similar structural mechanisms.
DOI 10.1101/2020.09.22.307959