Author

Željko M. Svedružić

University of RijekaORCID 0000-0002-0736-6182Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2

Frequent Co-Authors

Katarina VrbnjakiD· 1 shared Lucija OstojićiD· 1 shared Manuel Martinović· 1 shared Vedran MiletićiD· 1 shared Vesna Šendula JengićiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 4 mutual co-author links

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1 shared paperNeuroscience

Katarina VrbnjakORCID

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2 papers

Recent·Most cited

NeuroscienceInternational Journal of Molecular SciencesPeer-reviewedJan 17, 2023

Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer's disease

Željko M. Svedružić, Vesna Šendula Jengić, Lucija Ostojić

The paper shows that γ-secretase saturation with substrates leads to toxic effects in Alzheimer's disease by disrupting presenilin structures and increasing Aβ-protein production.

5 citations

statistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 22, 2020

Structural Analysis of Simultaneous Activation and Inhibition of Gamma-Secretase Activity in Development of Drugs for Alzheimers disease

Željko M. Svedružić, Katarina Vrbnjak, Manuel Martinović, Vedran Miletić

The paper investigates how biphasic drugs and pathogenic mutations affect gamma-secretase activity, showing they modulate amyloid-beta production through similar structural mechanisms.

DOI 10.1101/2020.09.22.307959

statistical model

𝕏 PostBluesky