A 3D Amphioxus Brain Atlas Illuminates the Blueprint of the Ancestral Chordate Brain
Che-Yi Lin, Wen-Hsin Hsu, Mei‐Yeh Jade Lu, Yi-Hua Chen, Yi‐Chih Chen, Yi‐Hsien Su, Shen‐Ju Chou, Jr‐Kai Yu
This study creates a 3D amphioxus brain atlas using single-nucleus RNA-seq and spatial transcriptomics, revealing ancestral brain organization and highlighting vertebrate innovations.
bioRxiv · Nov 27, 2025 · PreprintEvolutionary Biology