Author

Daniel J. Wackelin

Lawrence Livermore National LaboratoryORCID 0000-0001-8189-6985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

Christina S. Kang-YuniD· 1 shared Dan M. ParkiD· 1 shared Micaela FinneyiD· 1 shared Nathan DiplockiD· 1 shared Riyaz HaqueiD· 1 shared Sean P. LeonardiD· 1 shared Thomas DesautelsiD· 1 shared

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2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperSynthetic Biology

Christina S. Kang-YunORCID

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1 paper

Recent·Most cited

Synthetic BiologybioRxivPreprintAug 26, 2026

Unobserved Sequence Space Has Many Functional Proteins

Nathan Diplock, Thomas Desautels, Riyaz Haque…·Sean P. Leonard

The paper shows that unobserved protein sequence space contains many functional proteins, challenging the assumption that existing proteins cover most functional space.

DOI 10.64898/2026.08.24.746828

protein sequencestatistical model

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