Cancer BiologyPLoS Computational BiologyPeer-reviewed
Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy
Simon Syga, Harish P Jain, Marcus Krellner…·Andreas Deutsch
This paper investigates how somatic evolution and phenotypic plasticity interact in glioblastoma, showing that phenotypic heterogeneity, not genetic diversity, better predicts poor treatment outcomes.
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