Author

Brennan Klein

Northeastern UniversityORCID 0000-0001-8326-5044Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:multiple species· 1

Frequent Co-Authors

Anshuman SwainiD· 2 shared A TeufeliD· 1 shared April Snøfrid KleppeiD· 1 shared Erik P. HoeliD· 1 shared Keith SmithiD· 1 shared Laura StolpiD· 1 shared Ludvig HolmériD· 1 shared Mackenzie M. JohnsoniD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSystems Biology

Anshuman SwainORCID

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2 papers

Recent·Most cited

Systems BiologyCommunications BiologyPeer-reviewedDec 2, 2021

A computational exploration of resilience and evolvability of protein-protein interaction networks

Brennan Klein, Ludvig Holmér, Keith Smith…·April Snøfrid Kleppe

The paper evaluates how different node addition mechanisms affect the resilience of PPI networks across species, finding that gene-expression-based attachment best preserves resilience.

20 citations

E. coliyeast

𝕏 PostBluesky

Systems BiologybioRxivPreprintMay 3, 2020

Evolution leads to emergence: An analysis of protein interactomes across the tree of life

Erik P. Hoel, Brennan Klein, Anshuman Swain…·Michael G. Levin

The paper analyzes protein interactomes across 1800 species to show that biological networks develop macroscales associated with lower noise and higher resilience, particularly in eukaryotes.

8 citations

multiple speciesprotein structure

𝕏 PostBluesky