Denis Awany

Inflammatory Biomarkers of Asymptomatic and Symptomatic Tuberculosis

This study identifies transcriptomic and proteomic features of asymptomatic tuberculosis, revealing distinct sub-clusters and a new blood signature, but finds weaker diagnostic performance for asymptomatic cases compared to symptomatic ones.

Cross-species blood transcriptional correlates of BCG-mediated protection against tuberculosis include innate and adaptive immune processes

This study identifies cross-species blood transcriptional correlates of BCG-mediated protection against tuberculosis using a systems modeling framework, linking innate and adaptive immune processes to vaccine efficacy in humans and non-human primates.

Modelling Microbiome Association with Host Phenotypes Using a Bayesian Dirichlet Process Model

The paper introduces a Bayesian Dirichlet process model to analyze microbiome associations with host phenotypes, showing high statistical power in simulated and real datasets.

Heritability jointly Explained by Host Genotype and Microbiome:Will Improve Traits Prediction?

The paper discusses how incorporating microbiome data into GWAS can improve heritability estimation and trait prediction by addressing missing heritability.

Genome-Wide Association Studies of malaria susceptibility and resistance: progress, pitfalls and prospects

This paper reviews progress and challenges in GWAS of malaria susceptibility, highlighting the need for integrative approaches to understand genetic basis of resistance.