Author

Tennore Ramesh

University of SheffieldORCID 0000-0001-8398-5367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

Alexander McGowniD· 2 shared Adrian M. IsaacsiD· 1 shared Ahad A. RahimiD· 1 shared Alessia Fisher· 1 shared Alexander J. CammackiD· 1 shared Alla MikheenkoiD· 1 shared Alyssa N. CoyneiD· 1 shared Benedikt V. Hölbling· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Alexander McGownORCID

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2 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedJan 8, 2025

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Liam Kempthorne, Deniz Vaizoglu, Alexander J. Cammack…·Adrian M. Isaacs

This study demonstrates that CRISPR-CasRx reduces C9orf72 repeat RNAs and DPRs in vitro and in vivo, suggesting its therapeutic potential for ALS/FTD.

27 citationstop 1%

humanmouse

Molecular BiologyAnnals of NeurologyPeer-reviewedAug 31, 2024

RAN translation of C9orf72-related dipeptide repeat proteins in zebrafish recapitulates hallmarks of amyotrophic lateral sclerosis and identifies hypothermia as a therapeutic strategy

David Burrows, Alexander McGown, Olfat Abduljabbar…·Tennore Ramesh

This study creates a zebrafish model of C9orf72-ALS/FTD using RAN translation and shows hypothermia reduces DPR pathology and motor deficits.

2 citations

zebrafishexperimental assay