ImmunologyJournal of Translational MedicinePeer-reviewed
Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy
Haonan Yang, Zheng Lei, Jiang He…·Yongzhong Wu
This study uses single-cell RNA sequencing to show hypofractionated radiotherapy recruits CCL8high macrophages, reprograms them to an immunosuppressive state, and enhances tumor growth, which can be counteracted by CCL inhibitor Bindarit.