Author

John P. Ferguson

Ollscoil na Gaillimhe – University of GalwayORCID 0000-0001-8475-398XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:GWAS / association mapping· 2 Organism:human· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Amanda FordeiD· 2 shared Gibran HemaniiD· 2 shared Cathal SeoigheiD· 1 shared Declan BennettiD· 1 shared Derek W. MorrisiD· 1 shared Dónal O’SheaiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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2 shared papersGenetics

Amanda FordeORCID

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3 papers

Recent·Most cited

Simulated sample splitting approach to address biases due to instrument selection and participant overlap in two-sample Mendelian Randomization studies

Amanda Forde, Gibran Hemani, John P. Ferguson

The paper introduces MR-SimSS, a method to correct biases in two-sample MR studies by simulating independent data subsets from GWAS summary statistics, improving causal inference accuracy.

PLoS Genetics · May 8, 2026Peer-reviewedGenetics

Review and further developments in statistical corrections for Winner's Curse in genetic association studies

Amanda Forde, Gibran Hemani, John P. Ferguson

This paper reviews and improves statistical methods to correct for Winner's Curse in GWAS by evaluating simulated and real data, proposing a bootstrap method, and providing an R package.

PLoS Genetics · Sep 18, 2023Peer-reviewedGenetics

Controlling for background genetic effects using polygenic scores improves the power of genome-wide association studies

Declan Bennett, Dónal O’Shea, John P. Ferguson, Derek W. Morris, Cathal Seoighe

This paper shows that using polygenic scores to control for genetic background effects improves the power of genome-wide association studies and enhances phenotype prediction accuracy.

Scientific Reports · Oct 1, 2021Peer-reviewedGenomics