Derek W. Morris

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

This study identifies FOXP1-regulated genes across developmental stages and shows their enrichment for schizophrenia heritability, particularly in early childhood and adolescence.

This study identifies genetic loci associated with social participation and occupational engagement using UK Biobank data, finding genetic correlations with neuropsychiatric disorders and socioeconomic factors.

The paper shows SATB2 influences 3D genome structure in cortical neurons, affecting gene expression and cognitive-related functions.

This study identifies transcriptomic changes in mouse hippocampus due to social isolation and links them to human genetic risk factors for neurodevelopmental disorders.

The paper identifies MEF2C direct target genes enriched for schizophrenia and cognitive function genes, showing their involvement in neurogenesis and mitochondrial function.

This study compares XGBoost machine learning to polygenic scoring for predicting intelligence from genotype data, finding similar performance with fewer SNPs.

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

The paper identifies 13 genetic loci associated with cognitive resilience using GWAS-by-subtraction in UK Biobank data, showing enrichment in brain regions and cell types.

This paper shows that using polygenic scores to control for genetic background effects improves the power of genome-wide association studies and enhances phenotype prediction accuracy.

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

The paper reports exome sequencing findings in bipolar disorder, identifying AKAP11 as a shared risk gene with schizophrenia through ultra-rare protein-truncating variants.

The paper identifies genes regulated by MEF2C during neurodevelopment that are associated with schizophrenia, intelligence, and neurodevelopmental disorders, with different genetic variants affecting distinct cell types and phenotypes.

This study identifies DNA methylation changes in blood samples from psychosis patients, including treatment-resistant schizophrenia, and links them to biological age, smoking, and cellular composition.

The paper uses pleiotropic meta-analysis to identify genetic loci associated with cognition, education, and schizophrenia, revealing distinct biological mechanisms for concordant and discordant genetic correlations.

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

The paper identifies an excess of rare loss-of-function and missense mutations in voltage-gated sodium channels and synaptic genes associated with schizophrenia using large-scale sequencing and meta-analysis.

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.