Xin Zhao

This study shows that aneuploidy promotes ROS resistance by suppressing PARP1, which enhances metastasis, and identifies CEBPB as a key mediator of this process.

KaryoTap enables high-throughput single-cell aneuploidy profiling, revealing that positive and negative selection shape cancer genomes by influencing chromosomal gains and losses.

This study uses whole genome sequencing of cell-free DNA to identify tissue-of-origin patterns, achieving high specificity and sensitivity in cancer patients.