Teresa Davoli

This study assesses whether hydroquinone induces aneuploidy in hematopoietic stem cells using KaryoTap and FISH, finding no reproducible increase in whole-chromosome aneuploidy.

This study shows that lymph nodes actively drive melanoma evolution and immune evasion, linking regional metastasis to poor patient outcomes.

ZATELLITE enables real-time visualization and manipulation of human centromeres in live cells using synthetic zinc fingers without causing DNA damage.

This study shows Trisomy 21 impairs enteric neural crest development by reducing RET expression through SOD1-mediated oxidative stress.

conMItion adjusts confounding factors in multi-omics data to improve association measurements, identifying cancer-related genes and cell type associations in bladder and lung cancer.

COATS identifies copy-number-dependent oncogenes and tumor suppressors associated with aneuploidy across 33 cancer types, revealing genes that drive or enable chromosomal instability.

This study shows that aneuploidy promotes ROS resistance by suppressing PARP1, which enhances metastasis, and identifies CEBPB as a key mediator of this process.

This study identifies chromosome 1q gain as a biomarker for poor immunotherapy response in melanoma by linking aneuploidies to immune evasion mechanisms.

This study corrects a complex Chromosome 8 rearrangement in vitro, identifies differentially expressed genes, and shows partial rescue of neural differentiation defects.

The paper analyzes ORF1p expression across cancers, finding it correlates with immune suppression in some tumors and activation in others, linked to copy number alterations.

This study shows p53 inactivation is not universally linked to aneuploidy but is associated with increased chromosome loss in cancer.

KaryoTap enables high-throughput single-cell aneuploidy profiling, revealing that positive and negative selection shape cancer genomes by influencing chromosomal gains and losses.

This study demonstrates that a circular human artificial chromosome can be transmitted through three generations of mice without health or reproductive issues.

The paper describes a pipeline for de novo assembly, delivery, and expression of a 101 kb human gene in mouse cells, demonstrating functional evaluation of a full-length gene.