NeurosciencebioRxivPreprint
Intervention-consistent causal-source recovery from covariance-response geometry reveals upstream organisation in sporadic ALS
Shunya Kaneko, Makoto Urushitani
This paper introduces a framework to identify upstream organizational changes in sporadic ALS using single-nucleus RNA-seq data, revealing oligodendrocytes as structurally upstream and NEMF as a key gene with disease-specific co-expression loss.