Makoto Urushitani

This paper introduces a framework to identify upstream organizational changes in sporadic ALS using single-nucleus RNA-seq data, revealing oligodendrocytes as structurally upstream and NEMF as a key gene with disease-specific co-expression loss.

The paper shows that spinal cord extracts from sporadic ALS patients induce and spread TDP-43 pathology in human cerebral organoids, mimicking ALS pathophysiology.