BiochemistrybioRxivPreprint
Differential O-Glc elongation on the specific EGF repeat within a ligand binding domain regulates NOTCH1 signaling
Yohei Tsukamoto, Kazuhiro Aoki, Wataru Saiki…·Hideyuki Takeuchi
The paper identifies a specific O-glucose glycan extension on NOTCH1 EGF10 that impacts ligand binding and signaling, revealing new enzymatic pathways and structural features of Notch glycosylation.
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