Michael Tiemeyer

This paper identifies and characterizes two β-1,2-xylosyltransferases in Cryptococcus neoformans, showing they differentially impact glycan synthesis and capsule formation.

BiomarkerKB integrates and standardizes biomarker data from multiple sources to enable structured exploration and discovery of biomarker-disease relationships.

The paper describes the Common Fund Data Ecosystem (CFDE), which integrates NIH Common Fund data resources to enable discovery, analysis, and collaboration across heterogeneous datasets.

The paper introduces a knowledge graph framework for integrating and querying biomedical data across domains, demonstrating its utility in eight use cases.

The paper identifies a specific O-glucose glycan extension on NOTCH1 EGF10 that impacts ligand binding and signaling, revealing new enzymatic pathways and structural features of Notch glycosylation.

Genipin rescues developmental and degenerative defects in familial dysautonomia and enhances neuron regeneration after injury.

This study investigates how two ST3GAL5 variants cause GM3SD by analyzing GSL biosynthesis and signaling changes in patient-derived iPSCs and NCCs.

The paper identifies a bipartite sialylation pathway in Drosophila where glia and neurons perform distinct roles in regulating neural transmission and stress tolerance.

This paper describes a workflow to improve glycan data interoperability between ChEBI, PubChem, and GlyGen by integrating and prioritizing glycan annotations.