Cancer BiologybioRxivPreprint
Oxaliplatin and 5-Fluorouracil induce p53-p21-pRb-associated cell cycle arrest and a transient senescence-like phenotype in patient-derived low-grade serous ovarian cancer cells
Rewati Prakash, Benjamin N. Forgie, Alicia Alejandra Goyeneche…·Carlos Marcelo Telleria
This study shows that oxaliplatin and 5-fluorouracil induce a transient senescence-like phenotype and G0/G1-phase arrest in LGSOC cells via the p53-p21-pRb pathway, without killing the cells.
DOI 10.64898/2026.09.22.753519