Irene Nobeli

This study shows that OPA1 expression affects mitochondrial function and DNA content in neonatal hypoxia-ischaemia, with OPA1 loss leading to mitochondrial fragmentation and increased brain injury.

The paper constructs a whole genome co-expression network from Mycobacterium tuberculosis transcriptomic data to identify and prioritize unannotated expressed transcripts for functional analysis.

flexiMAP identifies differential alternative polyadenylation in RNA-seq data using beta-regression, outperforming existing methods in sensitivity and specificity.

baerhunter identifies and analyzes expressed non-coding regions in bacterial RNA-seq data by improving upon incomplete genome annotations.

The paper identifies an RNA switch in M. tuberculosis that co-regulates cell wall synthesis and ribosome maturation, suggesting a new drug target for tuberculosis.