Author

Brian M. Button

University of North Carolina at Chapel HillORCID 0000-0001-8623-0576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Kenichi OkudaiD· 2 shared Richard C. BoucheriD· 2 shared Wanda K. O’NealiD· 2 shared Adam BegemaniD· 1 shared Aditya R. JangidiD· 1 shared Alessandra Livraghi-ButricoiD· 1 shared Alexandra F. FreemaniD· 1 shared Alexandra SchäferiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Kenichi OkudaORCID

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2 papers

Recent·Most cited

Cell BiologyAmerican Journal of Respiratory and Critical Care MedicinePeer-reviewedJun 13, 2025

Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations

Ling Sun, Samantha A. Walls, Hong Dang…·Gang Chen

This study identifies airway epithelial host defense defects caused by STAT3 mutations in Hyper IgE Syndrome, contributing to chronic pulmonary infection.

7 citations

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsNature GeneticsPeer-reviewedJul 25, 2022

Genome-wide, bidirectional CRISPR screens identify mucins as critical host factors modulating SARS-CoV-2 infection

Scott B. Biering, Sylvia A. Sarnik, Eleanor Wang…·Patrick D. Hsu

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.

142 citationstop 1%

humanCRISPR screen

𝕏 PostBluesky