ImmunologybioRxivPreprint
Temporal Mechanisms of T-Cell Fate Decisions under Immune Checkpoint Blockade Resolved by CanonicalTockySeq
Jehanne Hassan, Omnia Reda, Nobuko Irie…·Masahiro Ono
This paper introduces CanonicalTockySeq to analyze T-cell fate decisions over time in immunotherapy, showing that effective treatment correlates with reduced antigen engagement and exhaustion signaling.