Masahiro Ono

Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8+ T cell reprogramming

This paper shows that intratumoural oncolytic HSV-1 reprograms systemic immunity by inducing specific CD8 T cell populations that correlate with clinical response to immunotherapy.

Preclinical efficacy of a systemically-administered, second-generation STING agonist that promotes antitumour immunity in combination with radiotherapy

This study evaluates a second-generation STING agonist, BI-1703880, showing that combining it with radiotherapy enhances antitumour immunity and immune memory.

Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8+ T-cell clonal dominance in head and neck cancer

This study shows that chemoradiotherapy (CRT) in head and neck cancer promotes clonal dominance of progenitor-exhausted CD8+ T-cells compared to radiotherapy alone.

Canonical Analysis of Fluorescent Timer-Anchored Transcriptomes Resolves Joint Temporal and Developmental Progression

The paper introduces mCanonicalTockySeq, a framework that integrates temporal and developmental progression using fluorescent timer data, showing it can map human thymic cells to a mouse reference and correlate temporal coordinates with age.

Temporal Mechanisms of T-Cell Fate Decisions under Immune Checkpoint Blockade Resolved by CanonicalTockySeq

This paper introduces CanonicalTockySeq to analyze T-cell fate decisions over time in immunotherapy, showing that effective treatment correlates with reduced antigen engagement and exhaustion signaling.

Regulation of TCR-induced Transcriptional Kinetics by Interleukin 2-inducible T Cell Kinase (ITK) in CD8+ T cells

This study shows ITK differentially regulates early and late TCR transcriptional responses by affecting the kinetics and termination of activation signals in CD8+ T cells.

Machine Learning-Assisted Decoding of Temporal Transcriptional Dynamics via Fluorescent Timer

This study uses CRISPR, Tocky, and machine learning to analyze Foxp3 transcription dynamics in mice, revealing CNS2-dependent regulation and age-related expression patterns.

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.

This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.