Temporal Mechanisms of T-Cell Fate Decisions under Immune Checkpoint Blockade Resolved by CanonicalTockySeq
Jehanne Hassan, Omnia Reda, Nobuko Irie, Malin Pedersen, Shane Foo, Lizzie Appleton, Il‐mi Okazaki, Taku Okazaki, Yorifumi Satou, Kevin Joseph Harrington, Alan A. Melcher, Masahiro Ono
This paper introduces CanonicalTockySeq to analyze T-cell fate decisions over time in immunotherapy, showing that effective treatment correlates with reduced antigen engagement and exhaustion signaling.
bioRxiv · Mar 12, 2026 · PreprintImmunology