Author

Patrick R. Sears

University of North Carolina at Chapel HillORCID 0000-0001-8656-957XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Lawrence E. OstrowskiiD· 2 shared Alexandra F. FreemaniD· 1 shared Amjad HoraniiD· 1 shared Anshulika Deshmukh· 1 shared Barbara R. GrubbiD· 1 shared Brian M. ButtoniD· 1 shared Camille EhréiD· 1 shared Charles R. EstheriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Lawrence E. OstrowskiORCID

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2 papers

Recent·Most cited

Cell BiologyAmerican Journal of Respiratory and Critical Care MedicinePeer-reviewedJun 13, 2025

Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations

Ling Sun, Samantha A. Walls, Hong Dang…·Gang Chen

This study identifies airway epithelial host defense defects caused by STAT3 mutations in Hyper IgE Syndrome, contributing to chronic pulmonary infection.

7 citations

humanbulk RNA-seq

GeneticsPLoS GeneticsPeer-reviewedAug 7, 2020

Mutation of CFAP57 causes primary ciliary dyskinesia by disrupting theasymmetric targeting of a subset of ciliary inner dynein arms

Ximena Minerva Bustamante-Marin, Amjad Horani, Mihaela Stoyanova…·Susan K. Dutcher

This study identifies mutations in CFAP57 as a cause of primary ciliary dyskinesia by showing they disrupt asymmetric inner dynein arm assembly in cilia.

49 citationstop 4%

humanmouse