Author

Caleb Kwame Sinclear

National Institutes of HealthORCID 0000-0001-8703-856XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Andres M. LebensohniD· 1 shared Joseph K. McKennaiD· 1 shared Praveen SonkusreiD· 1 shared Raj ChariiD· 1 shared Yalan WuiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperGenetics

Andres M. LebensohnORCID

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1 paper

Recent·Most cited

GeneticsPLoS GeneticsPeer-reviewedMay 27, 2025

The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability

Joseph K. McKenna, Yalan Wu, Praveen Sonkusre…·Andres M. Lebensohn

This study identifies HUWE1 as a regulator of WNT signaling through two mechanisms: antagonizing destruction complex-mediated β-catenin degradation and an independent pathway, both requiring HUWE1's ubiquitin ligase activity.

3 citations

humanexperimental assay

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