Joseph K. McKenna

This study shows that increasing MyoD1 levels in myoblasts expands its genome binding and upregulates cell adhesion genes, leading to impaired fusion but enhanced myotube contraction.

This study identifies HUWE1 as a regulator of WNT signaling through two mechanisms: antagonizing destruction complex-mediated β-catenin degradation and an independent pathway, both requiring HUWE1's ubiquitin ligase activity.

The paper identifies a gene regulatory subcircuit in zebrafish cardiac neural crest cells that is reactivated during heart regeneration.

The paper develops a method to generate variant libraries in vivo using base editing to study gene regulatory programs in multicellular organisms.

This study identifies TFEB as a transcriptional regulator of syncytiotrophoblast differentiation by controlling Syncytin-1 and Syncytin-2 expression in BeWo cells.