Cindy H. Wen

The paper analyzes psychosis biotypes using ancestry-adjusted polygenic risk scores and identifies genomic associations with specific biotypes in brain transcriptomes.

This study identifies 63 AMD risk loci across multiple ancestries, highlighting ancestry-dependent genetic heterogeneity and potential therapeutic targets.

The paper identifies cell-type-specific genetic regulation of RNA-editing and alternative polyadenylation in human neural progenitors and neurons, linking these to brain-related traits.

The paper constructs a cross-ancestry, cell-type-informed gene regulatory atlas of the developing human brain, identifying genetic regulation and linking it to neuropsychiatric disorders.

The paper introduces a new statistical method for multivariate variance components models to analyze brain isoform expression and identifies novel psychiatric disease mechanisms.

This paper introduces isoTWAS, a method that improves discovery of genetic risk mechanisms for neuropsychiatric disorders by analyzing isoform-level transcriptome-wide associations.