Carol A. Tamminga

Mapping the Psychosis Spectrum -- Imaging Neurosubtypes from Multi-Scale Functional Network Connectivity

This study identifies three psychosis neurosubtypes using imaging data, showing distinct connectivity patterns and supporting their biological validity through relative alignment.

ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations

The paper analyzes psychosis biotypes using ancestry-adjusted polygenic risk scores and identifies genomic associations with specific biotypes in brain transcriptomes.

Tau seeding without tauopathy

The paper detects seeding activity of tau assemblies in healthy human brains, suggesting normal physiological tau function that may contribute to disease when disrupted.

Transcriptional dissection of symptomatic profiles across the brain of men and women with depression

This study identifies sex-specific gene modules linked to MDD symptom domains in brain regions, revealing distinct transcriptional signatures in males and females.

Histone H3 serotonylation dynamics in dorsal raphe nucleus contribute to stress- and antidepressant-mediated gene expression and behavior

The paper investigates how serotonin modifies histone H3K4me3Q5ser dynamics in the dorsal raphe nucleus under stress and antidepressant exposure, showing its role in gene expression and behavior.

The Long Noncoding RNA FEDORA is a Cell-Type- and Sex-Specific Regulator of Depression

The paper identifies FEDORA, a lncRNA with sex- and cell-type-specific effects on depression in females.

Acetylated Chromatin Domains Link Chromosomal Organization to Cell- and Circuit-level Dysfunction in Schizophrenia and Bipolar Disorder

The paper identifies acetylated chromatin domains associated with dysfunction in schizophrenia and bipolar disorder by analyzing histone modifications in prefrontal cortex samples.

Regression dynamic causal modeling for resting-state fMRI

This paper introduces regression dynamic causal modeling (rDCM) for resting-state fMRI, providing directional connectivity estimates and scalability to whole-brain networks.

The genomic underpinnings of oscillatory biomarkers supporting successful memory encoding in humans

This paper links brain oscillations to gene expression in human patients, identifying gene modules associated with memory encoding and neuropsychiatric disorders.

Cell-type specific epigenetic links to schizophrenia risk in brain

The paper analyzes cell-type specific DNA methylation and transcriptomes in schizophrenia brains, finding reduced epigenetic distinction between cell types in schizophrenia.

Schizophrenia Exhibits Bi-Directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits

The paper identifies brain-wide bi-directional connectivity alterations in cortico-striato-cerebellar circuits in schizophrenia using resting-state fMRI and validates findings with clustering and classification methods.

Genetic Analysis of Deep Phenotyping Projects in Common Disorders

The paper discusses challenges in genetic analysis of deep phenotyping projects in common disorders and highlights advances in imputation and GWAS methods to address these challenges.

Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study

The paper reports GWAS findings linking common variants in NRXN1, LRP1B, and RORA to increased ventricular volumes in psychosis, using deep phenotyping data from 1,115 cases and controls.

Higher genetic risk of schizophrenia is associated with lower cognitive performance in healthy individuals

The paper investigates the association between schizophrenia genetic risk and cognitive performance in healthy individuals, finding a link with current cognitive abilities but not with premorbid intelligence or education.