DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION
Mingzhuo Zhang, Mingda Liu, Zhiyun Ren, Weiwan Wang, Kiran K. Upadhyay, Laureano D. Asico, Inés Armando, Yutao Jia, Ping Wang, Ying Xue, Xiaoyan Wang
This study shows that dopamine D4 receptor reduces NCC protein levels by promoting its ubiquitination and lysosomal degradation in mice.
bioRxiv · Feb 14, 2024 · PreprintPhysiology