Quanlei Wang

The paper uses single-cell transcriptomics to analyze cellular and molecular differences across maternal-fetal sections of the placenta, identifying key cell types and regulatory factors involved in placental development and preeclampsia.

The paper introduces scCAT-seq, a method to simultaneously assay chromatin accessibility and transcriptome in single cells, and demonstrates its application in human pre-implantation embryos to reveal regulatory heterogeneity.

This study uses single-cell RNA-seq to analyze transcriptome dynamics during human early neural differentiation, identifying novel transcription factors and regulatory elements involved in the process.