Dongsheng Chen

This paper develops a novel peripherally acting alpha2A-adrenergic receptor antagonist, CDS479-2, which improves glucose control in diabetic mice without central side effects.

The paper compares single-cell transcriptomic data of lung tissues from bats, cats, tigers, and pangolins to analyze viral receptor distribution and immune responses to respiratory viruses.

CDCP is a platform for sharing and analyzing single-cell datasets, offering visualization and analysis tools for researchers.

BDdb is a database integrating multi-omics data, cfDNA data, and biomarkers for birth defects, enabling data exploration and analysis for research and clinical applications.

This study creates the first single cell atlas of T21 cerebral cortex, identifying dysregulated genes and developing a platform for data exploration.

This study creates the first single-cell brain atlas of domestic pigs, identifies cell types and their spatial distribution, and compares them with other species to reveal evolutionary and disease-related insights.

The paper introduces scCAT-seq, a method to simultaneously assay chromatin accessibility and transcriptome in single cells, and demonstrates its application in human pre-implantation embryos to reveal regulatory heterogeneity.

This study uses single-cell RNA-seq to analyze transcriptome dynamics during human early neural differentiation, identifying novel transcription factors and regulatory elements involved in the process.