CYLD, a Mechanosensitive Deubiquitinase, Regulates TGFβ for Load-induced Bone Formation and Mediates PGE2-dependent Repression of TGFβ Signaling in Osteocytes
Jacqueline Nguyen, Ramin Massoumi, Tamara N. Alliston
The paper identifies CYLD as a mechanosensitive deubiquitinase that represses TGFβ signaling in osteocytes through PGE2 and EP2, facilitating load-induced bone formation.
bioRxiv · Aug 12, 2019Molecular Biology