Tamara N. Alliston

This study shows APOE4 affects female bone quality more than male bone, without structural changes, by disrupting osteocyte function.

This study uses spatial mass spectrometry imaging to identify ECM peptide markers distinguishing OA-affected subchondral bone from healthy tissue and less affected regions.

This study identifies OPG-secreting CAFs as immunosuppressive stromal cells and shows that blocking OPG promotes immune infiltration and tumor regression in mouse models.

This study investigates sex-specific differences in TGFβ regulation of perilacunar/canalicular remodeling in bone, showing that TGFβ inhibition affects bone quality differently in male and female mice.

The paper identifies CYLD as a mechanosensitive deubiquitinase that represses TGFβ signaling in osteocytes through PGE2 and EP2, facilitating load-induced bone formation.